Basic information Safety Supplier Related

PREGNENOLONE SULFATE SODIUM SALT

Basic information Safety Supplier Related

PREGNENOLONE SULFATE SODIUM SALT Basic information

Product Name:
PREGNENOLONE SULFATE SODIUM SALT
Synonyms:
  • PREGNENOLONE SULFATE SODIUM
  • PREGNENOLONE SULFATE SODIUM SALT
  • Pregnenolone monosulfate sodium salt
  • (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
  • PREGNENOLONE SULPHATE, SODIUM SALT
  • 3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT
  • 3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT
  • 3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT
CAS:
1852-38-6
MF:
C21H31NaO5S
MW:
418.52
Product Categories:
  • Steroids
Mol File:
1852-38-6.mol
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PREGNENOLONE SULFATE SODIUM SALT Chemical Properties

Melting point:
192 °C(lit.)
storage temp. 
Store at -20°C
solubility 
methanol and water: 1.93 mg/mL
form 
A crystalline solid
color 
White to off-white
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Safety Information

WGK Germany 
3

MSDS

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PREGNENOLONE SULFATE SODIUM SALT Usage And Synthesis

Description

Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

Uses

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

Uses

Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.

Biochem/physiol Actions

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

in vivo

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].

IC 50

CB1; Human Endogenous Metabolite

storage

Store at +4°C

References

[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH  David H F  Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL  Oliver G R  Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237

PREGNENOLONE SULFATE SODIUM SALTSupplier

J & K SCIENTIFIC LTD.
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