PREGNENOLONE SULFATE SODIUM SALT Chemical Properties

Melting point:

192 °C(lit.)

storage temp. 

Store at -20°C

solubility 

methanol and water: 1.93 mg/mL

form 

A crystalline solid

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

PREGNENOLONE SULFATE SODIUM SALT Usage And Synthesis

Description

Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

Uses

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

Uses

Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.

Biochem/physiol Actions

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

storage

Store at +4°C

PREGNENOLONE SULFATE SODIUM SALT(1852-38-6)Related Product Information

• Pregnenolone-[20,21-13C2, 16,16-d2] sulfate sodium salt (Solution)
• DIAMOND
• Pregnanolone-[d5]
• Pregnenolone-[20,21-13C2, 16,16-D2] sulfate sodium salt
• Sodium Pregnenolone-17α,21,21,21-d4 Sulfate
• PREGNENOLONE-17ALPHA,21,21,21-D4
• Pregnenolone-2,2,4,4-d4
• Pregnenolone-[20,21-13C2, 16,16-D2]
• 5-Pregnen-3β-ol-20-one-17α?21?21?21-d4 3-Methyl Ether
• Pregnenolone-[20,21-13C2, 16,16-d2]
• Pregnenolone
• 5-PREGNEN-3-BETA, 17-DIOL-20-ONE 3-SULPHATE SODIUM SALT
• PREGNENOLONE SULFATE SODIUM SALT
• PREGNENOLONE [7-3H(N)]-3-SULFATE, SODIUM SALT
• 21-HYDROXYPREGNENOLONE 3 SULPHATE
• SODIUM PREGNENOLONE-17ALPHA,21,21,21-D4 SULFATE