PREGNENOLONE SULFATE SODIUM SALT
PREGNENOLONE SULFATE SODIUM SALT Basic information
- Product Name:
- PREGNENOLONE SULFATE SODIUM SALT
- Synonyms:
-
- PREGNENOLONE SULFATE SODIUM
- PREGNENOLONE SULFATE SODIUM SALT
- Pregnenolone monosulfate sodium salt
- (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
- PREGNENOLONE SULPHATE, SODIUM SALT
- 3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT
- 3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT
- 3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT
- CAS:
- 1852-38-6
- MF:
- C21H31NaO5S
- MW:
- 418.52
- Product Categories:
-
- Steroids
- Mol File:
- 1852-38-6.mol
PREGNENOLONE SULFATE SODIUM SALT Chemical Properties
- Melting point:
- 192 °C(lit.)
- storage temp.
- Store at -20°C
- solubility
- methanol and water: 1.93 mg/mL
- form
- A crystalline solid
- color
- White to off-white
MSDS
- Language:English Provider:SigmaAldrich
PREGNENOLONE SULFATE SODIUM SALT Usage And Synthesis
Description
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
Uses
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).
Uses
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
storage
Store at +4°C
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PREGNENOLONE SULFATE SODIUM SALT(1852-38-6)Related Product Information
- Pregnenolone-[20,21-13C2, 16,16-d2] sulfate sodium salt (Solution)
- DIAMOND
- Pregnanolone-[d5]
- Pregnenolone-[20,21-13C2, 16,16-D2] sulfate sodium salt
- Sodium Pregnenolone-17α,21,21,21-d4 Sulfate
- PREGNENOLONE-17ALPHA,21,21,21-D4
- Pregnenolone-2,2,4,4-d4
- Pregnenolone-[20,21-13C2, 16,16-D2]
- 5-Pregnen-3β-ol-20-one-17α?21?21?21-d4 3-Methyl Ether
- Pregnenolone-[20,21-13C2, 16,16-d2]
- Pregnenolone
- 5-PREGNEN-3-BETA, 17-DIOL-20-ONE 3-SULPHATE SODIUM SALT
- PREGNENOLONE SULFATE SODIUM SALT
- PREGNENOLONE [7-3H(N)]-3-SULFATE, SODIUM SALT
- 21-HYDROXYPREGNENOLONE 3 SULPHATE
- SODIUM PREGNENOLONE-17ALPHA,21,21,21-D4 SULFATE