7-Bromobenz[A]Anthracene
7-Bromobenz[A]Anthracene Basic information
- Product Name:
- 7-Bromobenz[A]Anthracene
- Synonyms:
-
- 10-brom-1,2-benzanthracen
- 10-bromo-1,2-benzanthracene
- 7-bromo-benz(a)anthracen
- 7-bromobenzanthracene
- 7-BROMO-BENZ[A]ANTHRACENE 98+%
- 7-BROMOBENZ[A]ANTHRACENE
- Bromobenzanthracene
- AR-E 4 7-BROMOBENZ(A)ANTHRACENE
- CAS:
- 32795-84-9
- MF:
- C18H11Br
- MW:
- 307.18
- Mol File:
- 32795-84-9.mol
7-Bromobenz[A]Anthracene Chemical Properties
- Melting point:
- 152 °C
- Boiling point:
- 361.79°C (rough estimate)
- Density
- 1.3995 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Room Temperature, under inert atmosphere
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly)
- form
- Solid
- color
- Light Beige to Dark Yellow
- InChI
- InChI=1S/C18H11Br/c19-18-15-8-4-2-6-13(15)11-17-14-7-3-1-5-12(14)9-10-16(17)18/h1-11H
- InChIKey
- LGRNWCDRODWMOH-UHFFFAOYSA-N
- SMILES
- C12=CC=CC=C1C=CC1C2=CC2C(=CC=CC=2)C=1Br
7-Bromobenz[A]Anthracene Usage And Synthesis
Toxicity evaluation
The tumorigenicity of 7-chlorobenz[α]anthracene (7-C1-BA), an environmental contaminant, and 7-bromobenz[α]anthracene (7-Br-BA) was determined in the male B6C3F1 newborn mouse. Mice receiving 7-C1-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96% hepatocellular adenomas, and 100 and 83% hepatocellular carcinoma, respectively. Metabolism by liver microsomes of 15-day-old mice each produced the corresponding trans-3,4-dihydrodiol. Analysis by 32P-postlabeling/HPLC indicated the presence of DNA adducts derived from 7-C1-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol. The results indicate that both 7-C1-BA and 7-Br-BA are potent carcinogens and that bay-region diol epoxides are the ultimate metabolites that lead to DNA adduct formation and tumor initiation[1].
References
[1] Peter P. Fu. “Potent tumorigenicity of 7-chlorobenz[α]anthracene and 7-bromobenz[α]anthracene in the neonatal B6C3F1 male mouse.” Cancer letters 101 1 (1996): Pages 37-42.
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