BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties

Melting point:

25°C

Boiling point:

62-63 °C (lit.)

Density 

1.404 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.300(lit.)

Flash point:

35 °F

storage temp. 

Flammables area

solubility 

DMSO : ≥ 125 mg/mL (686.59 mM)

form 

clear liquid

Specific Gravity

1.41

color 

Colorless to Almost colorless

Merck 

14,4201

BRN 

1811927

CAS DataBase Reference

333-36-8(CAS DataBase Reference)

EPA Substance Registry System

HFE-356mff2 (333-36-8)

Safety Information

Hazard Codes 

F,Xi,T

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 3271 3/PG 2

WGK Germany 

3

RTECS 

KN3675000

Hazard Note 

Flammable/Toxic/Convulsant

HazardClass 

3.1

PackingGroup 

II

HS Code 

29091990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

BIS(2,2,2-TRIFLUOROETHYL) ETHER Usage And Synthesis

Chemical Properties

clear colorless liquid

Originator

Indoklon ,Ohio Medical, US ,1964

Uses

Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.

Uses

Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.

Uses

5HT agonist

Definition

ChEBI: Flurotyl is an ether.

Manufacturing Process

23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).

brand name

Indoklon (Ohmeda).

Therapeutic Function

Central stimulant, Convulsant

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