2-METHOXY-6-METHYLBENZOIC ACID ETHYL ESTER Chemical Properties

Boiling point:

135 °C / 15mmHg

Density 

1,09 g/cm³

refractive index 

1.5100 to 1.5130

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29189900

2-METHOXY-6-METHYLBENZOIC ACID ETHYL ESTER Usage And Synthesis

Synthesis

Ethyl 2-hydroxy-6-methylbenzoate (1.0 g, 5.6 mmol), iodomethane (866 mg, 6.1 mmol), and potassium carbonate (1.5 g, 11.1 mmol) were dissolved in acetone (20 mL) and the reaction was heated to reflux for 17 hours. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture and extracted with dichloromethane (3 × 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: 100% hexane) to afford ethyl 2-methoxy-6-methylbenzoate (1.1 g, 99% yield) as a colorless oil.

References

[1] Tetrahedron, 1991, vol. 47, # 40, p. 8635 - 8652
[2] Patent: KR101777971, 2017, B1. Location in patent: Paragraph 0138-0139
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 796 - 798

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