Sodium ketoisocaproate Chemical Properties

Melting point:

275 °C (dec.)(lit.)

storage temp. 

2-8°C

solubility 

Water (Slightly)

form 

Solid

color 

White to Off-White

Odor

at 100.00 %. butyric valeric buttery

Odor Type

buttery

JECFA Number

633.1

BRN 

4239297

Stability:

Hygroscopic

LogP

0.17

CAS DataBase Reference

4502-00-5(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25-22

WGK Germany 

3

MSDS

• Language:English Provider:4-Methyl-2-oxopentanoic acid sodium salt
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Sodium ketoisocaproate Usage And Synthesis

Occurrence

Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese.

Uses

Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method.

Uses

4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.

Biochem/physiol Actions

α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria.

Sodium ketoisocaproate(4502-00-5)Related Product Information

• Sodium bicarbonate
• METSULFURON METHYL
• Trisodium phosphate
• Pivalic acid
• Sodium chloride
• Methyl acrylate
• Sodium carbonate
• Diclofenac sodium
• Methylparaben
• Sodium benzoate
• MAGNESIUM DIPROPYLACETATE HYDRATE
• Kresoxim-methyl
• Sodium formate
• Bensulfuron methyl
• Estradiol valerate
• Sodium acetate
• 2-Propylpentanoic acid
• Sodium citrate