Gremubamab
Gremubamab Basic information
- Product Name:
- Gremubamab
- Synonyms:
-
- Gremubamab
- Research Grade Gremubamab (DXX03401)
- Research Grade Gremubamab
- CAS:
- 1800381-36-5
- MW:
- 0
- Mol File:
- Mol File
Gremubamab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Gremubamab Usage And Synthesis
Uses
Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections[1][2].
in vivo
Gremubamab (1, 5, 15 mg/kg; i.v.; at 1?h postinfection) improves survival outcomes in rabbit acute pneumonia model[2].
| Animal Model: | Rabbits (acute pneumonia model)[2] |
| Dosage: | 1, 5, 15 mg/kg |
| Administration: | I.v.; at 1?h postinfection |
| Result: | Improved survival outcomes in a dose-dependent manner in a rabbit acute pneumonia model. |
References
[1] Chastre J, et al. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. Crit Care. 2022 Nov 15;26(1):355. DOI:10.1186/s13054-022-04204-9
[2] Le HN, et al. Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00710-19. DOI:10.1128/AAC.00710-19
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