Gremubamab

Product Name: Gremubamab
CAS No.: 1800381-36-5
Chemical Name: Gremubamab
Synonyms: Gremubamab;Research Grade Gremubamab;Research Grade Gremubamab (DXX03401)
CBNumber: CB88081173
Formula Weight: 0
MOL File: Mol file

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Gremubamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Gremubamab Chemical Properties,Usage,Production

Uses

Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections[1][2].

in vivo

Gremubamab (1, 5, 15 mg/kg; i.v.; at 1?h postinfection) improves survival outcomes in rabbit acute pneumonia model^[2].

Animal Model:	Rabbits (acute pneumonia model)^[2]
Dosage:	1, 5, 15 mg/kg
Administration:	I.v.; at 1?h postinfection
Result:	Improved survival outcomes in a dose-dependent manner in a rabbit acute pneumonia model.

References

[1] Chastre J, et al. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. Crit Care. 2022 Nov 15;26(1):355. DOI:10.1186/s13054-022-04204-9
[2] Le HN, et al. Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00710-19. DOI:10.1128/AAC.00710-19

Gremubamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Gremubamab Suppliers

China 9 Global 9

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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Wuhan Chemstan Biotechnology Co., Ltd.

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Fax: QQ：422450190
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Biolab Reagents

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Shanghai Yifei Biotechnology Co. , Ltd.

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Atagenix Laboratories

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AntibodySystem Laboratories SAS

Tel: 33175446423
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Biosynth Biological Technology (Suzhou) Co Ltd

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Cell Sciences

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Guangzhou Chuangze Biotechnology Co., Ltd.

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1800381-36-5, GremubamabRelated Search:

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Gremubamab

Research Grade Gremubamab (DXX03401)

Research Grade Gremubamab

1800381-36-5