Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Basic information
- Product Name:
- Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Synonyms:
-
- Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Thalidomide-NH-C10-acid
- Pomalidomide-C10-COOH
- Thalidomide-4-NH-C10-COOH
- 11-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]undecanoic Acid
- CAS:
- 2428400-33-1
- MF:
- C24H31N3O6
- MW:
- 457.52
- Mol File:
- 2428400-33-1.mol
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Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemical Properties
- Boiling point:
- 718.9±55.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- pka
- 4.78±0.10(Predicted)
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Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Usage And Synthesis
Biological Activity
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based von Hippel-Lindau (VHL) ligand and a linker used in PROTAC technology[1].
References
[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654.
Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-Supplier
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Xian confluore Biological Technology Co., Ltd.
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