Ethyl L-serinate hydrochloride Chemical Properties

Melting point:

130-132 °C(lit.)

alpha 

-5 º (c=2, H2O)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Solid

color 

White to off-white

optical activity

[α]20/D 4.4°, c = 10.2 in ethanol

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

3562346

Major Application

peptide synthesis

InChI

InChI=1/C5H11NO3.ClH/c1-2-9-5(8)4(6)3-7;/h4,7H,2-3,6H2,1H3;1H/t4-;/s3

InChIKey

JZJQCLZQSHLSFB-NDILARRWNA-N

SMILES

C(=O)(OCC)[C@@H](N)CO.Cl |&1:5,r|

CAS DataBase Reference

26348-61-8(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29225090

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:Ethyl L-serinate hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl L-serinate hydrochloride Usage And Synthesis

Chemical Properties

white to beige needle-like crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Preparation of Ethyl L-serinate hydrochloride: To a three-necked flask equipped with a condenser tube, an off-gas absorber and an inlet device, add redistilled anhydrous ethanol (100 ml). Dry hydrogen chloride was passed for 1 hour to saturate the anhydrous ethanol with respect to the hydrogen chloride. It was then cooled in an ice bath, 3.5 g of serine was added, and stirring was continued in the ice bath by passing hydrogen chloride for 1 hour. The ice bath was removed and heated to reflux for half an hour. Cool, add 10 grams of anhydrous magnesium sulfate and dry for 24 hours. Filter off the desiccant, evaporate half of the solvent, refrigerator standing overnight, precipitation of colorless crystals, filtration, vacuum drying, and finally get a colorless crystalline product Ethyl L-serinate hydrochloride. Melting point: 160??160.8??, literature value 159??162??.

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