trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties

Melting point:

162 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;

InChIKey

UUHNQHFOIVLAQX-BJILWQEISA-N

SMILES

C(/CN(C)C)=C\C(=O)O.Cl

CAS DataBase Reference

848133-35-7(CAS DataBase Reference)

Safety Information

HS Code 

2922498590

trans-4-Dimethylaminocrotonic acid hydrochloride Usage And Synthesis

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical Properties

White Solid

Uses

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)Related Product Information

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