2-Chloro-4-bromoacetophenone Chemical Properties

Boiling point:

265.6±25.0 °C(Predicted)

Density 

1.566±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

Yellow

Safety Information

Hazard Codes 

Xn

HS Code 

2914790090

2-Chloro-4-bromoacetophenone Usage And Synthesis

Uses

2''-Chloro-4''-bromoacetophenone

Synthesis

Step 6-J: Methylmagnesium bromide (44 mL, 61.6 mmol, 1.4 M in tetrahydrofuran) was slowly added dropwise to tetrahydrofuran (50 mL) at -78 °C. Subsequently, a solution consisting of 4-bromo-2-chloro-N-methoxy-N-methylbenzamide (3.52 g, 12.7 mmol, from Step 6-I) dissolved in tetrahydrofuran (30 mL) was added. The reaction mixture was stirred at -78°C for 45 minutes, then brought to room temperature and continued stirring for 1.5 hours. After completion of the reaction, the mixture was extracted with ethyl acetate (3 times), the organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by recrystallization (solvent: ethyl acetate/hexane) to afford 1-(4-bromo-2-chlorophenyl)ethanone as a white solid (1.1 g, 37% yield).

References

[1] Patent: US2009/170920, 2009, A1. Location in patent: Page/Page column 13-14
[2] Patent: JP2015/231988, 2015, A

2-Chloro-4-bromoacetophenone(252561-81-2)Related Product Information

• 4-Methoxyphenacyl chloride
• 2-Bromo-2'-fluoroacetophenone
• 2'-BROMO-5'-FLUOROACETOPHENONE
• 3'-(Trifluoromethyl)acetophenone
• 2-Bromo-4'-fluoroacetophenone
• 4-Fluoroacetophenone
• 2',4'-Difluoroacetophenone
• 3'-(TRIFLUOROMETHOXY)ACETOPHENONE
• 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
• 2-Bromo-2',4'-difluoroacetophenone
• 4'-BROMO-3'-NITROACETOPHENONE
• 3'-Bromo-4'-fluoroacetophenone
• 3,5-DIFLUOROPHENACYL BROMIDE
• 4'-Fluoro-3'-nitroacetophenone
• 2-Chloro-4-bromobenzaldehyde
• 2-Chloro-4-bromoacetophenone
• 1-(4-BROMO-2,5-DICHLOROPHENYL)ETHANONE
• 1-(4-BROMO-2,5-DICHLOROPHENYL)-2-CHLOROETHANONE