NITROFEN Chemical Properties

Melting point:

69-70°C

Boiling point:

368 ºC

Density 

1.3

refractive index 

1.6140 (estimate)

Flash point:

205℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Solid

color 

White to Light yellow

Water Solubility 

1mg/L(22 ºC)

Merck 

14,6598

BRN 

1887356

Stability:

Stable. Incompatible with strong oxidizing agents.

NIST Chemistry Reference

2,4-Dichloro-4'-nitrodiphenyl ether(1836-75-5)

IARC

2B (Vol. 30, Sup 7) 1987

EPA Substance Registry System

Nitrofen (1836-75-5)

Safety Information

Hazard Codes 

T,N

Risk Statements 

45-61-50/53-22

Safety Statements 

45-53-61-60-50/53-22

RIDADR 

3077

WGK Germany 

3

RTECS 

KN8400000

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29093090

Hazardous Substances Data

1836-75-5(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 3.58 g/kg (Ambrose)

MSDS

• Language:English Provider:ALFA

NITROFEN Usage And Synthesis

Chemical Properties

Nitrofen is a crystalline solid.

Uses

Formerly as herbicide.

Definition

ChEBI: Nitrofen is an organic molecular entity. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a herbicide.

General Description

Colorless crystals or black solid. Used as a pre- or post-emergence herbicide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

NITROFEN is a nitrated and halogenated ether derivative.

Health Hazard

Nitrofen is moderately toxic by ingestionand inhalation of dusts. The lethal doses in cats from oral administration and inhalationof dusts are 300 mg/kg and 620 mg/m³/4h,respectively (NIOSH 1986). Bovine calvestreatedorally by 1.5 mL 25% nitrofen/kg produced toxic effects after 36–48 hours. Thesymptoms were increase in body temperature, depression, and progressive decrease inrespiration rate and pulse rate,similar to tribulin (Gupta and Singh 1985). An increase inthe activities of serum glutamic-oxaloacetictransaminase and glutamipyruvictransaminase was noted(Gupta and Singh 1984). Nitrofen has beenfound to cause cancer in animals. There issufficient evidence of its carcinogenicity inanimals (IARC). Oral administration in micecaused liver and lung cancers.

Fire Hazard

Flash point data for NITROFEN are not available; however, NITROFEN is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion. Moderately toxic by inhalation and possibly other routes. Experimental teratogenic and reproductive effects. A skin and severe eye irritant. Mutation data reported. A broad-spectrum herbicide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and ETHERS. When heated to decomposition it emits very toxic fumes of Cl and NOx.

Potential Exposure

Nitrofen is a contact herbicide used for pre-and post-emergency control of annual grasses and broadleaf weeds on a variety of food and ornamental crops. Occupational exposure to nitrofen, primarily through inhalation and dermal contact may occur among workers at production facilities. Field handlers of the herbicide are subject to inhalation exposure during application procedures.

Carcinogenicity

Nitrofen is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN3345 Phenoxyacetic acid derivative pesticide, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Waste Disposal

Small quantities may be landfilled but large quantities should be incinerated. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

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