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4-Cyanotetrahydropyran

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4-Cyanotetrahydropyran Basic information

Product Name:
4-Cyanotetrahydropyran
Synonyms:
  • 1,3,5-trichloro-2-(4-nitrophenoxy)-benzen
  • 1,3,5-Trichloro-2-(4-nitrophenoxy)benzene
  • 1-Nitro-4-(2,4,6-trichlorophenoxy)benzene
  • ether,p-nitrophenyl2,4,6-trichlorophenyl
  • Mc 1478
  • MC 338
  • mc1478
  • mc338
CAS:
1836-77-7
MF:
C12H6Cl3NO3
MW:
318.54
EINECS:
217-407-6
Mol File:
1836-77-7.mol
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4-Cyanotetrahydropyran Chemical Properties

Melting point:
105-106°
Boiling point:
206°C (rough estimate)
Density 
1.533
refractive index 
1.6200 (estimate)
storage temp. 
0-6°C
color 
Pale yellow needles
Water Solubility 
764ug/L(22 ºC)
BRN 
1890443
EPA Substance Registry System
Chlornitrofen (1836-77-7)
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Safety Information

Hazard Codes 
Xi,F,N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2904200090
Toxicity
LC50 in carp (48 hr): >10,000 mg/l; LC50 in flea (3 hr): >40,000 mg/l (Kanazawa)
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4-Cyanotetrahydropyran Usage And Synthesis

Synthesis

4-Cyanotetrahydropyran can be obtained by chlorination of phenol with chlorine gas to obtain 2,4,6-trichlorophenol, which is then condensed with p-nitrochlorobenzene.

Uses

Herbicide.

Definition

ChEBI: Chlornitrofen is an aromatic ether, a member of chlorobenzenes and a C-nitro compound. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a herbicide.

Safety Profile

Low toxicity by ingestion and skincontact. Mutation data reported. Used as an herbicide.When heated to decomposition it emits very toxic fumesof NOx and Clí.

Metabolic pathway

Degradation of chlornitrofen by microorganisms isolated from soils gives rise to the reduction of the nitro group of chlornitrofen to the amino analog, and the successive N-acetylation or N-methylation and the cleavage of the ether linkage are dominant metabolic pathways. The metabolic pathways, however, differ depending on microorganisms and the media. The replacement of the amino group by hydroxyl group, the reduction and successive formylation of p-nitrophenol, and the cleavage of the phenyl ring ultimately to produce CO2 are also observed.

4-Cyanotetrahydropyran Preparation Products And Raw materials

Raw materials

4-CyanotetrahydropyranSupplier

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