Tilogotamab
Tilogotamab Basic information
- Product Name:
- Tilogotamab
- Synonyms:
-
- Tilogotamab
- Research Grade Tilogotamab (DHA29106)
- Research Grade Tilogotamab
- CAS:
- 2109731-10-2
- MW:
- 0
- Mol File:
- Mol File
Tilogotamab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Tilogotamab Usage And Synthesis
Uses
Tilogotamab is an agonistic hexamer formation-enhanced mixture of two antibodies that target two separate epitopes on death receptor type 5 (DR5). Tilogotamab specifically binds to and activates DR5. Tilogotamab can be used for the research of multiple myeloma (MM)[1].
in vivo
Tilogotamab (20 μg/mL; 24 h) induces potent cytotoxicity of primary MM cells[1].
Tilogotamab is a mixture of 2 noncompeting DR5-specific immunoglobulin G1 (IgG1) antibodies, each with an E430G mutation in the Fc domain. This mutation enhances Fc-Fc interactions, resulting in antibody hexamerization, followed by FcγR-independent clustering of DR5 molecules[1].
References
[1] Horst HJ, et, al. Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2165-2172. DOI:10.1182/bloodadvances.2020003731
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