PMPA(NAALADaseinhibitor) Chemical Properties

Boiling point:

538.8±60.0 °C(Predicted)

Density 

1.658±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

Soluble to 100 mM in sterile

form 

powder

pka

2.06±0.10(Predicted)

color 

white to beige

Water Solubility 

Soluble to 100 mM in water

Safety Information

RTECS 

SA0454800

PMPA(NAALADaseinhibitor) Usage And Synthesis

Uses

2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.

Biological Activity

Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Biochem/physiol Actions

2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).

storage

Desiccate at RT

PMPA(NAALADaseinhibitor)(173039-10-6)Related Product Information

• 3-PHOSPHONOPROPIONIC ACID
• 5-PHOSPHONOPENTANOIC ACID
• PMPA(NAALADaseinhibitor)