Buparvaquone
Buparvaquone Basic information
- Product Name:
- Buparvaquone
- Synonyms:
-
- CS-1178
- 2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-4-naphthalenedione
- 2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone
- butalex
- 2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione
- BW-720C
- 2-((4-tert-butylcyclohexyl)Methyl)-3-hydroxynaphthalene-1,4-dione
- Buparvaquone-d4
- CAS:
- 88426-33-9
- MF:
- C21H26O3
- MW:
- 326.43
- EINECS:
- 618-162-1
- Product Categories:
-
- API
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- john's
- Mol File:
- 88426-33-9.mol
Buparvaquone Chemical Properties
- Melting point:
- 178-184°C
- Boiling point:
- 460.7±45.0 °C(Predicted)
- Density
- 1.158±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble
- form
- powder
- pka
- 5.04±0.10(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3
- InChIKey
- KLLIVCPQDTYMLC-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(=O)C(O)=C1CC1CCC(C(C)(C)C)CC1
- CAS DataBase Reference
- 88426-33-9(CAS DataBase Reference)
Buparvaquone Usage And Synthesis
Chemical Properties
Yellow Crystalline Solid
Uses
Analog of antimalarial hydroxynaphthoquinones; tert-butyl derivative of Parvaquone. Antiprotozoal (Theileria)
Biological Activity
Buparvaquone is a second-generation hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. Buparvaquone is indicated for the therapy and prophylaxis of all forms of Theileriosis and found to have an anti-Leishmanial activity.
in vivo
Treatment of N.?caninum infected mice with buparvaquone (100?mg/kg) either by intraperitoneal injection or gavage prevents neosporosis symptoms in 4 out of 6 mice in the intraperitoneally treated group, and in 6 out of 7 mice in the group receiving oral treatment[1]. Both a hydrous gel and water-in-oil emulsion of buparvaquone significantly reduce cutaneous parasite burden and lesion size, compared with the untreated control[3].
BuparvaquoneSupplier
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Buparvaquone(88426-33-9)Related Product Information
- Kresoxim-methyl
- Methanol
- Methylparaben
- tert-Butyldimethylsilyl chloride
- Atovaquone
- tert-Butyl methyl ether
- Basic Violet 1
- CHLOROPHOSPHONAZO III
- Acetonitrile
- Butylated hydroxyanisole
- Butylated Hydroxytoluene
- Methyl acrylate
- Methyl
- Naphthalene
- parvaquone
- 2-Hydroxy-1,4-naphoquinone
- 2-hydroxy-3-methyl-1,4-naphthoquinone
- Buparvaquone