3-Pyridinesulfonamide Chemical Properties

Melting point:

110-111 °C

Boiling point:

357.7±34.0 °C(Predicted)

Density 

1.417±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.43±0.60(Predicted)

form 

solid

color 

Pale yellow

InChI

InChI=1S/C5H6N2O2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H,(H2,6,8,9)

InChIKey

NKFLEFWUYAUDJV-UHFFFAOYSA-N

SMILES

C1=NC=CC=C1S(N)(=O)=O

Safety Information

HS Code 

2935909099

3-Pyridinesulfonamide Usage And Synthesis

Synthesis

General procedure for the synthesis of pyridine-3-sulfonamide from pyridine-3-sulfonyl chloride: Intermediate 78: Pyridine-3-sulfonamide; To a solution of pyridine-3-sulfonyl chloride (1 g, 5.6 mmol, 1 eq., commercially available from Davos) in tetrahydrofuran (THF, 5 mL) was added a solution of ammonia in dioxane (23.9 mL, 2 M, 47.9 mmol, 8.5 eq.). The resulting suspension was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by rotary evaporation and the residue was dissolved in dichloromethane (DCM). The organic phase was washed sequentially with saturated aqueous ammonium chloride (NH4Cl) and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the DCM. the product was dried under vacuum at 40 °C to afford 637 mg (71% yield) of the title compound as a pale yellow powder.1H NMR (DMSO-d6) δ 9.20-8.90 (m, 1H), 8.85-8.75 (m. 1H), 8.40-8.05 (m, 1H), 7.80-7.40 (m, 3H).

References

[1] Heterocycles, 2007, vol. 71, # 9, p. 1975 - 1990
[2] Patent: CN107098846, 2017, A. Location in patent: Paragraph 2373-2376
[3] Patent: WO2008/101979, 2008, A1. Location in patent: Page/Page column 85-86
[4] Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4889 - 4898
[5] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 58 - 66,9

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