Quinolin-3-yl-methanol Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Boiling point:

329.8±17.0 °C(Predicted)

Density 

1.218±0.06 g/cm3(Predicted)

Melting point:

65-67 °C

pka

13.68±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HazardClass 

IRRITANT

Quinolin-3-yl-methanol Usage And Synthesis

Synthesis

Step 1: Sodium borohydride (240 mg, 6.4 mmol) was added batchwise to a solution of quinoline-3-carbaldehyde (910 mg, 5.8 mmol) in methanol (10 mL) at room temperature. The reaction mixture was stirred for 3 hours and then the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL). Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with brine and dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the crude quinolin-3-ylmethanol (795 mg, 86% yield).

References

[1] Journal of Organic Chemistry, 1990, vol. 55, # 19, p. 5344 - 5347
[2] European Journal of Organic Chemistry, 2009, # 26, p. 4458 - 4467
[3] Patent: WO2008/115516, 2008, A2. Location in patent: Page/Page column 65
[4] Patent: WO2005/123724, 2005, A1. Location in patent: Page/Page column 73
[5] Heterocycles, 1999, vol. 51, # 8, p. 1883 - 1889

Quinolin-3-yl-methanol(13669-51-7)Related Product Information

• C-QUINOLIN-3-YL-METHYLAMINE
• methyl quinoline-3-carboxylate
• 5-HYDROXYMETHYLQUINOLINE
• Quinoline-5-carboxaldehyde
• QUINOLIN-7-YLBORONIC ACID
• 6-Quinolinecarbaldehyde
• 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
• 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
• 3-Quinolinecarboxylic acid
• 7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID
• ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
• 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID
• 4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLIC ACID
• 2,3-Quinoline dicarboxylic acid
• 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
• 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• 8-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER