3-CHLOROPHENACYL BROMIDE Chemical Properties

Melting point:

39 °C

Boiling point:

122-124℃

Density 

1.598±0.06 g/cm3(Predicted)

Flash point:

110 °C

storage temp. 

2-8°C

form 

Solid

Appearance

Off-white to yellow Solid

Sensitive 

Lachrymatory

CAS DataBase Reference

41011-01-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-39

RIDADR 

UN 3335

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory/Keep Cold

HazardClass 

IRRITANT

HazardClass 

9

HS Code 

2914790090

Hazardous Substances Data

41011-01-2(Hazardous Substances Data)

3-CHLOROPHENACYL BROMIDE Usage And Synthesis

Uses

2-Bromo-3'-chloroacetophenone acts as a Substrate used in a one-step preparation of symmetrical 1,4-diketones in the presence of Zn-I2.

Synthesis

Molecular sieve-dried 3-chloroacetophenone (154.6 g, 1 mol) was added to a four-necked flask with anhydrous methanol (310 mL) under nitrogen protection. Bromine (158.2 g, 0.99 mol) was slowly added dropwise under continuous stirring in the temperature range of 30 °C to 45 °C. The dropwise addition was controlled to be completed within 1 h. The reaction was carried out in a controlled manner. After the dropwise addition was completed, the reaction mixture was kept at the same temperature and stirring was continued for 10 minutes. Subsequently, water (160 g) was added and the reaction solution was cooled to -10°C to promote crystal precipitation. The precipitate was collected by filtration to give 250 g of crude product. The crude product was dissolved in heptane (750 g), washed twice sequentially with water (200 g) and the organic phase was dried with anhydrous magnesium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated to give 212.5 g of 2-bromo-3-chloroacetophenone in 91.0% yield, and no impurities were detected.

References

[1] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 16, p. 3045 - 3049
[3] Patent: US5717116, 1998, A
[4] Patent: US5831132, 1998, A
[5] Patent: EP2280000, 2011, A1. Location in patent: Page/Page column 40-41

3-CHLOROPHENACYL BROMIDE(41011-01-2)Related Product Information

• 2-Bromo-1-(2,5-dichlorophenyl)ethanone
• 2-Bromo-3'-chloropropiophenone
• 3-CHLOROPHENACYL BROMIDE
• 2-BROMO-1-(3-CHLORO-4-METHYLPHENYL)PROPAN-1-ONE
• (DICHLOROMETHYL)DIMETHYLCHLOROSILANE
• 2-BROMO-1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE
• 4-CHLOROPHENACYL BROMIDE
• 2-Chlorophenacyl bromide, tech,o-Chlorophenacyl bromide,2&#39-Chlorophenacyl bromide,2-CHLOROPHENACYL BROMIDE,2'-CHLOROPHENACYL BROMIDE
• 4-Chloro-2'-bromoacetophenone
• Acetyl bromide
• 3'-Chloroacetophenone
• 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYL-3-NITRO-PHENYL)ETHANONE
• 3-BROMO-6-CHLOROCHROMONE
• 3-BROMO-6-CHLORO-7-METHYLCHROMONE
• 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYLPHENYL)ETHANONE
• 2-BROMO-1-(3,5-DICHLORO-2-METHOXYPHENYL)ETHANONE
• 2-BROMO-3' 5'-DICHLORO-2'-HYDROXYACETOP&
• 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE