3-CHLOROPHENACYL BROMIDE
- Product Name
- 3-CHLOROPHENACYL BROMIDE
- CAS No.
- 41011-01-2
- Chemical Name
- 3-CHLOROPHENACYL BROMIDE
- Synonyms
- BUTTPARK 41\03-60;Tuloterol Impurity 9.;CHLOROPHENACYL BROMIDE;Tulobuterol Impurity 9;m-Chlorophenacyl bromide;3-CHLOROPHENACYL BROMIDE;2-Bromo-m-chloroacetophenone;3-Chlorophenacyl bromide 97%;2-BROMO-3'-CHLOROACETOPHENONE;alpha-bromo-3-chloroacetophenone
- CBNumber
- CB9128776
- Molecular Formula
- C8H6BrClO
- Formula Weight
- 233.49
- MOL File
- 41011-01-2.mol
3-CHLOROPHENACYL BROMIDE Property
- Melting point:
- 39 °C
- Boiling point:
- 122-124℃
- Density
- 1.598±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- 2-8°C
- form
- Solid
- Appearance
- Off-white to yellow Solid
- Sensitive
- Lachrymatory
- CAS DataBase Reference
- 41011-01-2(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-39
- RIDADR
- UN 3335
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HazardClass
- IRRITANT
- HazardClass
- 9
- HS Code
- 2914790090
- Hazardous Substances Data
- 41011-01-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 672823
- Product name
- 2-Bromo-3′-chloroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $51.7
- Updated
- 2023/01/07
- Product number
- 672823
- Product name
- 2-Bromo-3′-chloroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $190
- Updated
- 2023/01/07
- Product number
- C428070
- Product name
- 3-Chlorophenacylbromide
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 017212
- Product name
- 3-Chlorophenacylbromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- OR0271
- Product name
- 3-Chlorophenacylbromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
3-CHLOROPHENACYL BROMIDE Chemical Properties,Usage,Production
Uses
2-Bromo-3'-chloroacetophenone acts as a Substrate used in a one-step preparation of symmetrical 1,4-diketones in the presence of Zn-I2.
Synthesis
99-02-5
41011-01-2
Molecular sieve-dried 3-chloroacetophenone (154.6 g, 1 mol) was added to a four-necked flask with anhydrous methanol (310 mL) under nitrogen protection. Bromine (158.2 g, 0.99 mol) was slowly added dropwise under continuous stirring in the temperature range of 30 °C to 45 °C. The dropwise addition was controlled to be completed within 1 h. The reaction was carried out in a controlled manner. After the dropwise addition was completed, the reaction mixture was kept at the same temperature and stirring was continued for 10 minutes. Subsequently, water (160 g) was added and the reaction solution was cooled to -10°C to promote crystal precipitation. The precipitate was collected by filtration to give 250 g of crude product. The crude product was dissolved in heptane (750 g), washed twice sequentially with water (200 g) and the organic phase was dried with anhydrous magnesium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated to give 212.5 g of 2-bromo-3-chloroacetophenone in 91.0% yield, and no impurities were detected.
References
[1] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 16, p. 3045 - 3049
[3] Patent: US5717116, 1998, A
[4] Patent: US5831132, 1998, A
[5] Patent: EP2280000, 2011, A1. Location in patent: Page/Page column 40-41
3-CHLOROPHENACYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLOROPHENACYL BROMIDE manufacturers
- Product
- 3-Chlorophenacyl Bromide 41011-01-2
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-25