illudin S Chemical Properties

Melting point:

124-126℃

Boiling point:

327.55°C (rough estimate)

Density 

1.0583 (rough estimate)

refractive index 

1.4300 (estimate)

storage temp. 

-20°C, Inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

A light yellow solid

pka

12.50±0.70(Predicted)

color 

Off-white to yellow

illudin S Usage And Synthesis

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G₁-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC₅₀ = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

Uses

Illudin S is a potent antitumor sesquiterpene.

Uses

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

Definition

ChEBI: Illudin S is a sesquiterpenoid.

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