Cryptochlorogenic acid Chemical Properties

Boiling point:

694.9±55.0 °C(Predicted)

Density 

1.65

storage temp. 

2-8°C

solubility 

DMSO : 50 mg/mL (141.12 mM; Need ultrasonic)

form 

Solid

pka

4.07±0.50(Predicted)

color 

White-pale yellow

optical activity

[α]/D -76.0±5.0°, c = 0.5 in H2O

Stability:

Hygroscopic

InChI

InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/t11-,12-,14-,16+/m1/s1

InChIKey

GYFFKZTYYAFCTR-NCZKRNLISA-N

SMILES

O([C@H]1[C@@H](C[C@](C[C@H]1O)(O)C(=O)O)O)C(=O)C=CC1C=CC(=C(C=1)O)O

Safety Information

WGK Germany 

3

Cryptochlorogenic acid Usage And Synthesis

Chemical Properties

White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Eucommia ulmoides, Lonicera japonica, and Honeysuckle.

Uses

Cryptochlorogenic acid may be used as a reference standard in the determination of cryptochlorogenic acid in the leaves of Hibiscus sabdariffa using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS).

Uses

4-O-Caffeoylquinic acid has been used as a reference compound for the quantification in high performance liquid chromatography-diode array detector (HPLC-DAD).

Definition

ChEBI: A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 4-hydroxy group of (+)-quinic acid.

General Description

Cryptochlorogenic acid is a polyphenol, found in a variety of plants, which plays a crucial role in protection against various age-related diseases.

Biochem/physiol Actions

4-O-Caffeoylquinic acid (4-CQA) is a major active antioxidant marker in mulberry leaf extract. It is an inhibitor of ferroptosis hence, it is recognized as a potent anti-diabetic agent. 4-CQA plays an important role in the upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.

in vivo

IC 50

HIF-1α

Cryptochlorogenic acid(905-99-7)Related Product Information

• Quinidine
• Quinic acid
• Glycine
• Ethyl 2-(Chlorosulfonyl)acetate
• Neochlorogenic acid
• Quinine sulfate dihydrate
• Isochlorogenic acid A
• Tris(trimethylsilyl)phosphate
• Chlorogenic acid
• Folic acid
• illudin S
• Cryptotanshinone
• Triptolide
• Leucocrystal Violet
• Ginkgolide A
• Citric acid
• Ascoric Acid
• Quinine