HYDROXOCOBALAMIN HYDROCHLORIDE Chemical Properties

storage temp. 

2-8°C

solubility 

methanol: 10 mg/mL at 20 °C, clear, dark red

Safety Information

WGK Germany 

3

F 

3-8-10

MSDS

• Language:English Provider:SigmaAldrich

HYDROXOCOBALAMIN HYDROCHLORIDE Usage And Synthesis

Uses

Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO5- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant[1][2][3].

IC 50

Human Endogenous Metabolite

References

[1] Ling Xia, et al. Studies on the formation of glutathionylcobalamin: any free intracellular aquacobalamin is likely to be rapidly and irreversibly converted to glutathionylcobalamin. Inorg Chem. 2004 Oct 18;43(21):6848-57. DOI:10.1021/ic040022c
[2] Maria Lehene, et al. Adduct of Aquacobalamin with Hydrogen Peroxide. Inorg Chem. 2021 Sep 6;60(17):12681-12684. DOI:10.1021/acs.inorgchem.1c01483
[3] Ilia A Dereven'kov, et al. Aquacobalamin Accelerates Orange II Destruction by Peroxymonosulfate via the Transient Formation of Secocorrinoid: A Mechanistic Study. Int J Mol Sci. 2022 Oct 7;23(19):11907. DOI:10.3390/ijms231911907

HYDROXOCOBALAMIN HYDROCHLORIDE(13422-52-1)Related Product Information

• HYDROXOCOBALAMIN HYDROCHLORIDE
• Hydroxocobalamin
• Hydroxocobalamin Hydrochloride