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Hydroxocobalamin

Basic information Uses Safety Supplier Related

Hydroxocobalamin Basic information

Product Name:
Hydroxocobalamin
Synonyms:
  • alpha-(5,6-dimethylbenzimidazolyl)hydroxocobamide
  • alphacobione
  • alpharedisol
  • axion
  • axlon
  • ciplaminh
  • cobalex
  • vitaminb(sub12a)
CAS:
13422-51-0
MF:
C62H90ClCoN13O15P
MW:
1382.82
EINECS:
236-533-2
Product Categories:
  • pharmaceutical intermediate
Mol File:
13422-51-0.mol
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Hydroxocobalamin Chemical Properties

Melting point:
>300 °C
storage temp. 
2-8°C
solubility 
methanol: 10 mg/mL at 20 °C, clear, dark red
form 
Solid
color 
Dark Brown to Black
Odor
odorless
Stability:
Hygroscopic
InChIKey
YOZNUFWCRFCGIH-ZKJXODNJNA-K
LogP
-2.812 (est)
EPA Substance Registry System
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) (13422-51-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GG3820000
3-8-10
Hazardous Substances Data
13422-51-0(Hazardous Substances Data)
Toxicity
LD50 intravenous in mouse: > 50mg/kg

MSDS

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Hydroxocobalamin Usage And Synthesis

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate; a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Originator

Alpha-Redisol,MSD,US,1962

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Definition

A form of vitamin B 12.

Manufacturing Process

A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken with 78 mg of platinum oxide catalyst and hydrogen gas under substantially atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During the absorption of hydrogen the color of the solution changed from red to brown. The solution was separated from the catalyst and evaporated to dryness in vacuo. The residue was then dissolved in 1 ml of water and then diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3 mg) was formed and was then separated from the solution. This solution was diluted with an additional 2 ml of acetone and again allowed to stand for several hours. During this time about 4 to 5 mg of noncrystalline precipitate formed. This solid was separated from the solution and an additional 2 ml of acetone was added to the solution. On standing, vitamin B12a began to crystallize in the form of red needles. After standing for 24 hours, the crystalline material was separated, yield 12 mg. By further dilution of the mother liquor with acetone additional crystalline precipitate formed (from US Patent 2,738,302).

Therapeutic Function

Hematopoietic vitamin

Side effects

Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare.

Hydroxocobalamin Preparation Products And Raw materials

Preparation Products

HydroxocobalaminSupplier

INTATRADE GmbH
Tel
+49 3493/605464
Email
sales@intatrade.de
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Email
3001272453@qq.com