1-N-Boc-3-Cyanopyrrolidine Chemical Properties

Boiling point:

307.9±35.0 °C(Predicted)

Density 

1.08±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-3.73±0.40(Predicted)

form 

solid

color 

Pale yellow

CAS DataBase Reference

476493-40-0(CAS DataBase Reference)

Safety Information

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

3439

HazardClass 

6.1

PackingGroup 

III

HS Code 

2933998090

MSDS

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1-N-Boc-3-Cyanopyrrolidine Usage And Synthesis

Uses

1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities.

Synthesis

A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield).

References

[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60

1-N-Boc-3-Cyanopyrrolidine(476493-40-0)Related Product Information

• N-Vinyl-2-pyrrolidone
• Methyl acrylate
• BUTYL OLEATE
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• Dibutyl phthalate
• N-Methyl-2-pyrrolidone
• Methyl 4-cyanobenzoate
• RESMETHRIN
• Pyrrolidine
• Cyhalofop-butyl
• 1-Methylpyrrolidine
• Tris(trimethylsilyl)phosphate
• Povidone iodine
• tert-Butanol
• Polyvinylpyrrolidone
• 4-Cyanobenzoic acid
• METHYL-2-PYRROLIDONE
• 1-Boc-3-cyano-4-oxopyrrolidine