2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINALDEHYDE Chemical Properties

Boiling point:

225.3±40.0 °C(Predicted)

Density 

1.499±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-5.80±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2933399990

2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-chloro-6-(trifluoromethyl)nicotinaldehyde from (2-chloro-6-(trifluoromethyl)pyridin-3-yl)methanol: In a 100 mL round bottom flask, add (2-chloro-6-(trifluoromethyl)pyridin-3-yl)methanol (1.00 g, 4.73 mmol), dichloromethane (10 mL), PCC (2.04 g, 9.45 mmol. Aldrich) and silica gel (6.00 g). The reaction mixture was stirred at room temperature for 3 hours before being filtered through a pad of silica gel and washed with a 4:1 solvent mixture of ethyl acetate/hexane. The filtrate was concentrated under vacuum to give 2-chloro-6-(trifluoromethyl)nicotinaldehyde (0.805 g, 81% yield) as a colorless oil.1H NMR (CDCl3) δ 10.50 (s, 1H), 8.42 (d, J = 7.8 Hz, 1H), 7.80 (d, J = 7.8 Hz, 1H).

References

[1] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 105-106
[2] Patent: WO2013/64460, 2013, A1. Location in patent: Page/Page column 127

2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINALDEHYDE(944900-06-5)Related Product Information

• 1-(2-chloro-6-(trifluoromethyl)pyridin-3-yl)ethanone
• 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINALDEHYDE
• 2-Chloro-6-(trifluoromethyl)pyridine
• 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINAMIDE
• 2-Chloro-6-trifluoromethylnicotinic acid