4,6-DIFLUOROPYRIMIDINE Chemical Properties

Boiling point:

125℃

Density 

1.376

Flash point:

29℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-4.88±0.17(Predicted)

form 

liquid

color 

Clear, yellow

InChI

InChI=1S/C4H2F2N2/c5-3-1-4(6)8-2-7-3/h1-2H

InChIKey

MCLDVUCSDZGNRR-UHFFFAOYSA-N

SMILES

C1=NC(F)=CC(F)=N1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-41

Safety Statements 

26-36/37/39-39

HazardClass 

IRRITANT

HS Code 

2933599590

4,6-DIFLUOROPYRIMIDINE Usage And Synthesis

Synthesis

a) Preparation of 4,6-difluoropyrimidine (STR13): 4,6-dichloropyrimidine (223.5 g, 1.5 mol), potassium fluoride (279.6 g, 4.8 mol) and tetrabutylammonium bromide (6.0 g, 0.0186 mol) were dissolved in cyclobutanesulfone (1 L). The reaction mixture was heated at 180-190 °C for 3.5 h followed by distillation to afford the target product 4,6-difluoropyrimidine as a white liquid (115 g, 66% yield).

References

[1] Patent: US5977363, 1999, A
[2] Patent: US5977363, 1999, A
[3] Patent: EP794177, 1997, A1
[4] Patent: EP794177, 1997, A1
[5] Chemistry Letters, 1993, # 3, p. 509 - 512

4,6-DIFLUOROPYRIMIDINE(2802-62-2)Related Product Information

• 4-AMINO-2,6-DIFLUOROPYRIMIDINE
• 4,5,6-TRIFLUOROPYRIMIDINE
• 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE
• 2,4,6-TRIFLUOROPYRIMIDINE
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• 5-BROMO-2,4-DIFLUOROPYRIMIDINE
• 2,4-Difluoropyrimidine 98%,2,4-Difluoropyrimidine98%,2,4-DIFLUOROPYRIMIDINE
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• 2,4,6-TRIFLUORO-5-METHYLPYRIMIDINE
• 2-MORPHOLINO-4,6-DIFLUOROPYRIMIDINE,98%
• 5-BROMO-4,6-DIFLUOROPYRIMIDINE
• 4,6-DIFLUOROPYRIMIDINE
• 4,5,6-TRIFLUORO-2-TRIFLUOROMETHYL-PYRIMIDINE
• 2,5-Difluoropyrimidine
• 5-CHLORO-2,4-DIFLUOROPYRIMIDINE
• 6-[4-(1-Amino-2-sodiosulfo-9,10-dioxo-9,10-dihydroanthracen-4-ylamino)-N-(2-carboxyethyl)anilino]-5-chloro-2,4-difluoropyrimidine
• 2,4-DIFLUOROPYRIMIDINE-5-BORONIC ACID