2,4-DIFLUOROPYRIMIDINE Chemical Properties

Boiling point:

118-120 °C

Density 

1.359 g/mL at 25 °C

refractive index 

n20/D 1.432

Flash point:

106 °F

pka

-2.52±0.20(Predicted)

form 

liquid

color 

Clear, colourless

CAS DataBase Reference

2802-61-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

10-22-37/38-41

Safety Statements 

26-39

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

2,4-DIFLUOROPYRIMIDINE Usage And Synthesis

Synthesis

Crown ethers are able to enhance the performance of KF in two ways. Firstly, they complex the potassium cation making a better fluoride source and secondly they increase the solubility of KF in the solvent. KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted 2,4-dichloropyrimidine into 2,4-difluoropyrimidine.

Uses

2,4-Difluoropyrimidine can be used as a starting material to synthesize:

• 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH₁) inhibitors.
• N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137

2,4-DIFLUOROPYRIMIDINE(2802-61-1)Related Product Information

• 5-chloro-2,4-difluoropyrimidine
• 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE
• 2-MORPHOLINO-4,6-DIFLUOROPYRIMIDINE,98%
• 2,5-Difluoropyridine
• 3,5-Difluoropyridine
• 3,5-Difluoropyridine-2,6-diamine
• 5-BROMO-2,4-DIFLUOROPYRIMIDINE
• 4-AMINO-2,6-DIFLUOROPYRIMIDINE
• 5-Chloro-2,4,6-trifluoropyrimidine
• 2,4,6-TRIFLUOROPYRIMIDINE
• 2,4-DIFLUOROPYRIMIDINE
• 5-Chloro-2,3-difluoropyridine
• 2-AMINO-4,6-DIFLUOROPYRIMIDINE
• 4-Amino-3,5-dichloro-2,6-difluoropyridine
• 2,3-Difluoropyridine
• 2,6-Difluoropyridine-3-boronic acid
• 3,5-DICHLORO-2,6-DIFLUOROPYRIDINE
• 4-Pyrimidinamine,2,6-difluoro-N-methyl-