3,5-Difluoropyridine Chemical Properties

Boiling point:

92-93°C

Density 

1.256 g/mL at 25 °C

refractive index 

1.4437

Flash point:

9°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

pka

0.39±0.20(Predicted)

color 

Colorless to Almost colorless

BRN 

7914363

InChIKey

WRXAZPPGFLETFR-UHFFFAOYSA-N

CAS DataBase Reference

71902-33-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,F,N,Xn

Risk Statements 

36/37/38-50-20/21/22-11

Safety Statements 

26-36/37/39-61-36/37

RIDADR 

1993

WGK Germany 

3

Hazard Note 

Highly Flammable/Irritant

HazardClass 

3

PackingGroup 

II

HS Code 

29333990

MSDS

• Language:English Provider:3,5-Difluoropyridine
• Language:English Provider:ALFA

3,5-Difluoropyridine Usage And Synthesis

Synthesis

Hydrogenolysis of 2,4,6-tribromo-3,5-difluoropyridine occurred rapidly giving quantitative conversion to 3,5-difluoropyridine (5), with an isolated yield by distillation of 63%.

Chemical Properties

Liquid

Preparation

Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8.

3,5-Difluoropyridine(71902-33-5)Related Product Information

• DIPIPERIDINOMETHANE
• 2,6-Lutidine
• 2,5-PYRIDINEDICARBOXYLIC ACID
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• 2,3,5,6-Tetrafluoropyridine
• 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&
• 2,3-DIFLUOROPYRIDINE
• 2,5-DIFLUOROPYRIDINE
• 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE
• 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE
• 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
• Pentafluoropyridine
• 2,6-DIFLUOROPYRIDINE
• 3,4-DIBROMO-2-FLUOROPYRIDINE
• 5,6-Difluoropyridine-2-carboxylic acid
• 2,6-DIBROMO-3,5-DIFLUOROPYRIDINE-4-CARBOXYLIC ACID
• 2,6-DIFLUOROPYRIDINE-3-BORONIC ACID HYDRATE
• 2,4-DIFLUORO-PYRIDINE