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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Basic information

Product Name:
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Synonyms:
  • DILUDINE
  • DIETHYL 2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
  • DIETHYL 2,6-DIMETHYL-1,4-DIHYDROPYRIDINEDICARBOXYLATE
  • DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
  • AURORA 4780
  • 3,5-DICARBETHOXY-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE
  • 3,5-BIS(CARBOETHOXY)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE
  • 2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER
CAS:
1149-23-1
MF:
C13H19NO4
MW:
253.29
EINECS:
214-561-6
Product Categories:
  • Pyridines, Pyrimidines, Purines and Pteredines
  • C9 to C46
  • Pharmaceutical Intermediates
  • Heterocyclic Building Blocks
  • Pyridines
  • C9 to C46
  • Heterocyclic Building Blocks
  • fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, pharmaceutical intermediates
  • Building Blocks
  • C13 to C15
  • Chemical Synthesis
  • Heterocycle-Pyridine series
  • 1149-23-1
Mol File:
1149-23-1.mol
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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties

Melting point:
178-183 °C(lit.)
Boiling point:
351.8±42.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in organic solvents.
pka
3.50±0.70(Predicted)
form 
Solid
color 
Yellow
λmax
374nm(EtOH)(lit.)
InChI
InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
InChIKey
LJXTYJXBORAIHX-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O
CAS DataBase Reference
1149-23-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
2
RTECS 
US7970100
HS Code 
29333990
Toxicity
LD50 oral in dog: > 12gm/kg

MSDS

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Usage And Synthesis

Chemical Properties

Light green solid

Uses

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.

Uses

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.

Application

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.

Hazard

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Toxicology

rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg

Synthesis

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.

Purification Methods

recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateSupplier

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