Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties

Melting point:

178-183 °C(lit.)

Boiling point:

351.8±42.0 °C(Predicted)

Density 

1.104±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in organic solvents.

pka

3.50±0.70(Predicted)

form 

Solid

color 

Yellow

λmax

374nm(EtOH)(lit.)

InChI

InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3

InChIKey

LJXTYJXBORAIHX-UHFFFAOYSA-N

SMILES

C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O

CAS DataBase Reference

1149-23-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

2

RTECS 

US7970100

HS Code 

29333990

Toxicity

LD50 oral in dog: > 12gm/kg

MSDS

• Language:English Provider:SigmaAldrich

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Usage And Synthesis

Chemical Properties

Light green solid

Uses

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.

Uses

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.

Application

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.

Hazard

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Toxicology

rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg

Synthesis

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.

Purification Methods

recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate(1149-23-1)Related Product Information

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• Dimethyl phthalate
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• Dimethyl sulfoxide
• Dimethyl disulfide
• 2,5-PYRIDINEDICARBOXYLIC ACID
• Mefenpyr-diethyl
• Diethyl oxalate
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• Dimethyl ether
• ETHANE