methyl 2-chloropyrimidine-4-carboxylate Chemical Properties

Boiling point:

304.3±15.0 °C(Predicted)

Density 

1.372±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

-3.78±0.20(Predicted)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

36/37/39

WGK Germany 

3

HS Code 

29335990

methyl 2-chloropyrimidine-4-carboxylate Usage And Synthesis

Uses

Methyl 2-chloropyrimidine-4-carboxylate is an organic ester, which can be used as an intermediate in pharmaceutical synthesis for experimental research and pharmaceutical synthesis.

Synthesis

Synthesis of methyl 2-chloropyrimidine-4-carboxylate: 2-chloropyrimidine-4-carboxylic acid (4.76 g, 30 mmol) was dissolved in dichloromethane (30 mL) and dimethylformamide (0.3 mL), to which was added Slowly add oxalyl chloride (5.72g, 45mmol) dropwise, stir at room temperature for 2 hours, Chemicalbook, after concentrating to an appropriate volume, add dropwise to anhydrous methanol (50mL) placed under ice bath conditions, after the dropwise addition, the reaction is transferred to The reaction was carried out at room temperature for 2 hours, and concentrated under reduced pressure to obtain (5.17 g, yield 100%).

methyl 2-chloropyrimidine-4-carboxylate(149849-94-5)Related Product Information

• 2-Chloropyrimidine
• 2,4,5-Trichloropyrimidine
• Trichloropyrimidine
• 5-Chloropyrimidine
• PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER