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DIETHYLPROPION

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DIETHYLPROPION Basic information

Product Name:
DIETHYLPROPION
Synonyms:
  • 1-Phenyl-2-diethylamino-1-propanone
  • 2-(diethylamino)-1-phenyl-1-propanon
  • 2-(Diethylamino)-1-phenyl-1-propanone
  • 2-(diethylamino)-propiophenon
  • 2-(diethylamino)propiophenone
  • 2-(Diethylaminopropio)phenone
  • 2-diethylamino-propiophenon
  • 2-diethylaminopropiophenone
CAS:
90-84-6
MF:
C13H19NO
MW:
205.3
EINECS:
202-019-1
Mol File:
90-84-6.mol
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DIETHYLPROPION Chemical Properties

Boiling point:
292℃
Density 
0.972
refractive index 
1.5175 (estimate)
Flash point:
95℃
pka
8.49±0.25(Predicted)
EPA Substance Registry System
Diethylpropion (90-84-6)
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Safety Information

Hazardous Substances Data
90-84-6(Hazardous Substances Data)
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DIETHYLPROPION Usage And Synthesis

Originator

Tenuate,Merrell National ,US,1959

Uses

appetite depressant;stimulating secretion of norepinephrine

Definition

ChEBI: An aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity.

Manufacturing Process

1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.

brand name

Adiposan;Adipyn;Alipid;Amfepromone;Apisate;Bonumin;Brenalalit;Brendalit;Controlgras;D.i.p.n;Delgamer;Deramix;Dietec;Dietil retard;Dietil-retard;Lineal-plus;Lineal-rivo;Lineal-valeas;Linea-valeas;Lipomin;Liposlim;Menutil;Moderatan diffucap;Nobensin-75;Nobensine;Nobesine-25;Nulobes;Perfamone;Prefamone;Redicres;Regenon retard;Regibon;Sinapet;Slim-plus;Super emegrin;T-712;Tenuate dospan;Tenucap.

Therapeutic Function

Anorexic

World Health Organization (WHO)

Amfepramone, a phenethylamine derivative introduced in 1957, is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. It remains available in many other countries with highly evolved drug regulatory authorities as an aid to weight reduction.(Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)

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