4-(Trimethylsilyl)-3-butyn-2-one Chemical Properties

Melting point:

99 °C

Boiling point:

156 °C(lit.)

Density 

0.854 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.442(lit.)

Flash point:

83 °F

storage temp. 

Flammables area

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

0.854

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

CAS DataBase Reference

5930-98-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

16-26-36-37/39

RIDADR 

UN 1224 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29319090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4-(Trimethylsilyl)-3-butyn-2-one Usage And Synthesis

Chemical Properties

clear slightly yellow liquid

Uses

4-(Trimethylsilyl)-3-butyn-2-one (TMSB) has been used to investigate its asymmetric bioreduction to (S)-4-(trimethylsilyl)-3-butyn-2-ol {(S)-TMSBOL} by employing biocompatible water-immiscible ionic liquids (ILs). TMSB may be used for the synthesis of entecavir (BMS-200475).

General Description

4-(Trimethylsilyl)-3-butyn-2-one is a ketone. Its asymmetric bioreduction to enantiopure {(S)-TMSBOL in various hydrophilic ionic liquid (ILs) solvent systems has been reported.

4-(Trimethylsilyl)-3-butyn-2-one(5930-98-3)Related Product Information

• Norgestrel
• Mesotrione
• N-Methyl-2-pyrrolidone
• 3-Methyl butynol
• 4-Methyl-2-pentanone
• METHYL-2-PYRROLIDONE
• 3-Butyn-2-one
• 1-CYCLOPROPYL-3-TRIMETHYLSILANYL-PROPYNONE
• 4-CHLORO-1-TRIMETHYLSILANYL-PENT-1-YN-3-ONE
• 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
• 4-CHLORO-1-TRIMETHYLSILANYL-HEX-1-YN-3-ONE
• 1-PHENYL-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
• 1-BROMO-1-PHENYL-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
• 4-(Trimethylsilyl)-3-butyn-2-one