LX-1606 Hippurate
LX-1606 Hippurate Basic information
- Product Name:
- LX-1606 Hippurate
- Synonyms:
-
- LX-1606 Hippurate
- LX 1606
- LX 1606 (Telotristat)
- ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate
- Telotristat Impurity 1（Ethyl Telotristat）
- TELOTRISTAT ETHYL;LX1606;LX-1606
- L-Phenylalanine, 4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyriMidinyl]-, ethyl ester, LX-1606
- Telotristat ethyl
- CAS:
- 1033805-22-9
- MF:
- C27H26ClF3N6O3
- MW:
- 574.98
- Mol File:
- 1033805-22-9.mol
LX-1606 Hippurate Chemical Properties
- Melting point:
- 80-82°C
- Boiling point:
- 704.7±70.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.72±0.33(Predicted)
- form
- Solid
- color
- White to Off-White
- InChIKey
- MDSQOJYHHZBZKA-GBXCKJPGSA-N
- SMILES
- C(OCC)(=O)[C@H](CC1=CC=C(C2C=C(O[C@H](C3=CC=C(Cl)C=C3N3C=CC(C)=N3)C(F)(F)F)N=C(N)N=2)C=C1)N
LX-1606 Hippurate Usage And Synthesis
Uses
Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.
in vivo
Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2].
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