CINANSERIN HYDROCHLORIDE Chemical Properties

Melting point:

82-83 °C

Boiling point:

519.5±50.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

RTECS 

UC6323000

storage temp. 

Desiccate at RT

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

13.46±0.70(Predicted)

color 

White to Off-White

Water Solubility 

Soluble to 50 mM in water

CINANSERIN HYDROCHLORIDE Usage And Synthesis

Uses

Serotonin inhibitor.

Uses

A 5-HT antagonist

Definition

ChEBI: Cinanserin is an aryl sulfide that is (2E)-3-phenyl-N-(2-sulfanylphenyl)prop-2-enamide in which the hydrogen of the thiol group is substituted by a 3-(dimethylamino)propyl group. It is a 5-hydroxytryptamine receptor antagonist and an inhibitor of SARS-CoV replication. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an antiviral agent and an anticoronaviral agent. It is a tertiary amino compound, a secondary carboxamide, a member of cinnamamides and an aryl sulfide. It is a conjugate base of a cinanserin(1+).

Biological Activity

5-HT 2 antagonist.

in vivo

IC 50

5-HT₂ Receptor: 41 nM (Ki); 5-HT₁ Receptor: 3500 nM (Ki); SARS-CoV 3CLpro: 49.4 μM (Kd)

CINANSERIN HYDROCHLORIDE(1166-34-3)Related Product Information

• Agelongine
• Anpirtoline hydrochloride
• 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
• CINANSERIN HYDROCHLORIDE
• CINANSERIN HYDROCHLORIDE