ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide Basic information
- Product Name:
- 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
- Synonyms:
-
- 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
- 1,2,5-Thiadiazolidin-3-one, 5-phenyl-, 1,1-dioxide
- PTP1B-IN-1
- PTP1B inhibitor 1
- 1,1-Dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one
- Inhibitor,PTP-1B-IN-1,PTP1BIN1,inhibit,Phosphatase,PTP1B IN 1
- PTP1B-IN-1, 10 mM in DMSO
- CAS:
- 612530-44-6
- MF:
- C8H8N2O3S
- MW:
- 212.23
- Mol File:
- 612530-44-6.mol
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5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide Chemical Properties
- Density
- 1.483
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 38 mg/mL (179.05 mM)
- pka
- 4.23±0.20(Predicted)
- form
- Powder
- color
- White to yellow
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5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide Usage And Synthesis
Uses
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-Dioxide is used in the structure-based design of protein tyrosine phosphatase-1B inhibitors.
in vivo
PTP1B-IN-1 (0.1-1 μg, intrathecal injection, single dose) inhibits ER stress and NF-κB activation, exhibits analgesic and anti-inflammatory effects in rats spared nerve injury (SNI) models[3].
| Animal Model: | Rats SNI models[3] |
| Dosage: | 0.1-1 μg |
| Administration: | intrathecal injection, single dose |
| Result: | Increased the paw withdrawal threshold (PWT). |
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxideSupplier
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