4-Methyl-3-(hydroxyMethyl)Morpholine Chemical Properties

Boiling point:

201.1±15.0 °C(Predicted)

Density 

1.031±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.85±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2934999090

4-Methyl-3-(hydroxyMethyl)Morpholine Usage And Synthesis

Synthesis

Step 2: Preparation of (4-methylmorpholin-3-yl)methanol To a solution of morpholin-3-ylmethanol (0.540 g, 4.6 mmol) in methanol (20 mL) was added formaldehyde (1.86 g, 23 mmol, 37% aqueous solution) and palladium/carbon catalyst (0.200 g). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.0 atm). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: methanol:dichloromethane=1:15) to afford (4-methylmorpholin-3-yl)methanol (0.130 g, 22% yield) as a yellow oil.

References

[1] Patent: US2016/168090, 2016, A1. Location in patent: Paragraph 0927-0928

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