Elamipretide Chemical Properties

Density 

1.34±0.1 g/cm3(Predicted)

solubility 

Methanol (Slightly), Water (Slightly)

pka

10.10±0.25(Predicted)

form 

Solid

color 

White to Off-White

Sequence

H-d-Arg-dimethylTyr-Lys-Phe-NH2

Stability:

Hygroscopic

InChIKey

SFVLTCAESLKEHH-WKAQUBQDSA-N

SMILES

C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=C(C)C=C(O)C=C1C)NC(=O)[C@@H](CCCNC(N)=N)N

Elamipretide Usage And Synthesis

Description

Elamipretide, also known as MTP 131, is a mitochondria-targeted peptide antioxidant. Elamipretide decreases inflammation and protect against a variety of neurological illnesses. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.

Uses

D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide-d5 Trifluoroacetic Acid Salt is labelled D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (A769700) which is a mitochondrial-targeted compound that re-energizes ischemic mitochondria by interacting with cardiolipin. It is a cell-permeable antioxidant peptide.

Mechanism of action

Elamipretide can inhibit the production of pathogenic ROS (reactive oxygen species) and restore mitochondrial ATP synthesis. Currently, the most accepted mechanism for these two actions is the direct interaction between Elamipretide and cardiolipin.

Side effects

Side effects of elamipretide include:
Mild redness or itching at the injection site
Headache
Dizziness

Elamipretide(736992-21-5)Related Product Information

• Hexapeptide-11
• L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-threonyl-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1→17)-disulfide
• DERMASEPTIN PHYLLOMEDUSA SAUVAGII
• Vantas
• Eptifibatide Acetate
• DSIP
• Ipamorelin
• 2'-Deoxyadenosine
• Bithionol
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