DERMASEPTIN PHYLLOMEDUSA SAUVAGII Chemical Properties

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

Lyophilized powder

color 

White to off-white

Sequence

H-Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

DERMASEPTIN PHYLLOMEDUSA SAUVAGII Usage And Synthesis

Uses

Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against?bacteria,?fungi, and protozoa?at micromolar concentration[1].

Biological Activity

Dermaseptin is a polypeptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi and protozoa.

in vitro

Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration.

Source

Dermaseptin is derived from insect antimicrobial peptides; mammalian antimicrobial peptides; amphibian antimicrobial peptides; fish, mollusk and crustacean derived antimicrobial peptides; plant antimicrobial peptides and bacterial antimicrobial peptides.

References

[1] Mor A, et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. DOI:10.1021/bi00100a014
[2] Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9. PMID:8294443

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