CECROPIN A Chemical Properties

storage temp. 

-20°C

form 

powder

color 

White to off-white

Water Solubility 

Water : ≥ 50 mg/mL (12.14 mM)

Sequence

H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CECROPIN A Usage And Synthesis

Uses

Cecropin A is an antibacterial peptide originally identified in moths.

Uses

Cecropin A has been used as an antimicrobial peptide (AMP):

• to test its cytotoxic effect on breast adenocarcinoma (MDA-MB-231) and human mesothelioma (M14K) cell lines
• in ultrasensitive radial diffusion assay against E coli to test Galleria mellonella protein 24 and apolipophorin III effects
• to test its minimal inhibitory concentrations (MICs) in sensitivity assay for Photorhabdus variants

General Description

Cecropin A belongs to cecropin class and comprises 37 amino acid residues in L configuration. Structurally, this peptide has a C-terminal hydrophobic α-helical structure and the amphipathic N-terminal end. Cecropin A is linear and cationic in nature.

Biochem/physiol Actions

Cecropin A interacts with cell membranes and makes it permeable for electrolytes. Cecropin A thus, favors cytolysis and finally cell death in the hepatocellular carcinoma and lymphoma. The synthetic cecropin A in transgenic rice confers protection against bacterial as well as fungal pathogens.

CECROPIN A(80451-04-3)Related Product Information

• Cecropin A (1-8)-Melittin (1-18) amide H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-NH2
• Cecropin B (free acid) trifluoroacetate salt H-Lys-Trp-Lys-Val-Phe-Lys-Lys-Ile-Glu-Lys-Met-Gly-Arg-Asn-Ile-Arg-Asn-Gly-Ile-Val-Lys-Ala-Gly-Pro-Ala-Ile-Ala-Val-Leu-Gly-Glu-Ala-Lys-Ala-Leu-OH trifluoroacetate salt
• CECROPIN A (1-8)-MELITTIN A (3-9) AMIDE,CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE,CECROPIN A-MELITTIN HYBRID PEPTIDE
• CECROPIN B
• Tris(2,4-pentanedionato)chroMiuM(III)
• PHENYLSELENOL
• COBALT(II) ACETYLACETONATE
• Benzyl isocyanide
• Ethyl isocyanoacetate
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• TERT-BUTYL ISOCYANIDE
• METHYL ISOCYANOACETATE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• SALCOMINE
• Aluminum acetylacetonate
• N-BUTYLISOCYANIDE