ACK1-B19 Chemical Properties

Density 

1.283±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml

form 

A crystalline solid

pka

10.18±0.20(Predicted)

ACK1-B19 Usage And Synthesis

Description

XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC₅₀ value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC₅₀s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC₅₀ = >1 μM).

Uses

XMD8-87 is used in the studies of benzopyrimidodiazepinones as most selective and potent ERK5 inhibitor.

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