Phenoxyacetonitrile Chemical Properties

Boiling point:

235-238 °C(lit.)

Density 

1.09 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.524(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

2206192

CAS DataBase Reference

3598-14-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

RIDADR 

3276

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Phenoxyacetonitrile Usage And Synthesis

Chemical Properties

clear light yellow-brown liquid

Uses

Phenoxyacetonitrile is a building block that has been used as a reactant for the preparation of [[(oxo)pyridazinyl]phenoxy]acetonitrile derivatives to be used as vasodilators.

Uses

Phenoxyacetonitrile may be used in the synthesis of:

• 2,4-dihydroxyphenoxyacetophenones
• methylthio(phenoxy)acetonitrile
• 2,4-diamino-5-(3,4,5-trimethoxyphenoxy)pyrimidine

References

[1] M. HAMANA T. H Y Fujimura. Reactions of quinoline and 4-chloroquinoline 1-oxides with phenoxyacetonitrile, chloromethylphenylsulfone, and methyl-thiomethyl-p-tolylsulfone[J]. Heterocycles, 1987, 25 1: 229-233. DOI:10.3987/S-1987-01-0229.
[2] A. Jonczyk* Essa H M. A SIMPLE PROCEDURE FOR THE PREPARATION OF (METHYL- AND PHENYLTHIO)ARYLOXYACETONITRILES[J]. Organic Preparations and Procedures International, 1993, 25 1: 690-693. DOI:10.1080/00304949309356267.
[3] STOGRYN E L. Synthesis of trimethoprim variations. Replacement of methylene by polar groupings[J]. Journal of Medicinal Chemistry, 1972, 15 2: 200-201. DOI:10.1021/jm00272a019.

Phenoxyacetonitrile(3598-14-9)Related Product Information

• 4-(tert-Butyl)phenoxyacetonitrile, tech.
• 2-CHLOROPHENOXYACETONITRILE
• 2-(3,5-DICHLOROPHENOXY)ACETONITRILE
• 3-(Trifluoromethyl)phenoxyacetonitrile 97%,3-(Trifluoromethyl)phenoxyacetonitrile97%,3-(TRIFLUOROMETHYL)PHENOXYACETONITRILE
• 4-METHOXYPHENOXYACETONITRILE
• 3-CHLOROPHENOXYACETONITRILE
• 4-(2-THIAZOLIN-2-YL)PHENOXYACETONITRILE
• 4-NITROPHENOXYACETONITRILE
• PHENOXYACETONITRILE
• 2-(2,4-DICHLOROPHENOXY)ACETONITRILE
• 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONITRILE
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPANENITRILE
• 2-(4-Chlorophenoxy)acetonitrile
• 4-METHYLPHENOXYACETONITRILE
• 2-(2-FORMYL-6-METHOXYPHENOXY)ACETONITRILE
• (2-METHOXYPHENOXY)ACETONITRILE
• 2-BROMOPHENOXYACETONITRILE, 99
• 2-(4-BROMOPHENOXY)ACETONITRILE