DIISOPROPYLDICHLOROSILANE Chemical Properties

Melting point:

<0°C

Boiling point:

66 °C27 mm Hg(lit.)

Density 

1.026 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.444

Flash point:

43°C

solubility 

sol most organic solvents.

form 

clear liquid

Specific Gravity

1.026

color 

Colorless to Light yellow to Light orange

Hydrolytic Sensitivity

8: reacts rapidly with moisture, water, protic solvents

BRN 

1736244

CAS DataBase Reference

7751-38-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

10-34

Safety Statements 

28-36/37/39-45

RIDADR 

UN 2986 8/PG 2

WGK Germany 

3

F 

10-21

TSCA 

No

HazardClass 

3/8

PackingGroup 

II

HS Code 

29319090

MSDS

• Language:English Provider:SigmaAldrich

DIISOPROPYLDICHLOROSILANE Usage And Synthesis

Physical properties

bp 50–55°C/5 mmHg.

Uses

Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson alkenation reaction. The use of silicon groups as protection for hydroxy groups has been widely exploited.3 One potentially useful way to protect a nucleoside is by using a protecting group which spans the 3- and 5-hydroxy groups. One of the useful groups which can be used as a bifunctional protecting group in nucleosides is the diisopropylsilyl group. Reaction of the nucleoside with dichlorodiisopropylsilane and imidazole in DMF gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting group is a tetraisopropyldisiloxy group.

Preparation

conveniently prepared by the reaction of diisopropylsilane in carbon tetrachloride with palladium(II) chloride at 140°C for 8 h in a steel bomb.Washing the residue with ether and removing the ether by rotary evaporation yields the product which is purified by distillation to yield a clear colorless oil.

DIISOPROPYLDICHLOROSILANE(7751-38-4)Related Product Information

• DIMESITYLDICHLOROSILANE
• Dichloromethylvinylsilane
• DIISOPROPYLETHOXYSILANE
• Chlorodimethylsilane
• Dimethyldimethoxysilane
• DICHLOROISOBUTYLMETHYLSILANE
• DIISOBUTYLCHLOROSILANE
• DIISOBUTYLDIETHOXYSILANE
• Diisobutyldimethoxysilane
• 3,6-BIS(TERT-BUTYL)CARBAZOLE
• DICYCLOHEXYLDICHLOROSILANE
• DI-TERT-BUTYLDICHLOROSILANE
• DIISOPROPYLCHLOROSILANE
• Dichlorodiethylsilane
• DIISOPROPYLDICHLOROSILANE
• DIISOPROPYLSILANE
• ISOPROPYLMETHYLDICHLOROSILANE
• Dicyclopentyldichlorosilane