LENAMPICILLIN HYDROCHLORIDE
LENAMPICILLIN HYDROCHLORIDE Basic information
- Product Name:
- LENAMPICILLIN HYDROCHLORIDE
- Synonyms:
-
- (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-d-alpha-aminobenzylpenicillinatehyd
- -2-carboxylicacid,hydrochloride
- -amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane
- ampicillin,(5-methyl-2-oxo-1,3-dioxolen-4-yl)methylester,hydrochloride
- carbonicacid,cyclic1-(hydroxymethyl)-2-methylethyleneester,esterwith6-(2
- kb1585
- kbt1585
- kbt-1585
- CAS:
- 80734-02-7
- MF:
- C21H23N3O7S
- MW:
- 461.49
- Product Categories:
-
- Amines
- Drug Analogues
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 80734-02-7.mol
LENAMPICILLIN HYDROCHLORIDE Chemical Properties
- Melting point:
- 145° (dec)
- storage temp.
- Store at -20°C, sealed storage, away from moisture and light
- solubility
- DMSO:100.0(Max Conc. mg/mL);200.82(Max Conc. mM)
- form
- Solid
- color
- White to off-white
LENAMPICILLIN HYDROCHLORIDE Usage And Synthesis
Uses
Lenampicillin is an oral ampicillin prodrug. Antibiotic used in the treatment of respiratory tract infections and urinary tract infections.
Definition
ChEBI: Valacillin (TN) is a peptide.
in vivo
Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis[2].Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver[3].
LENAMPICILLIN HYDROCHLORIDESupplier
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LENAMPICILLIN HYDROCHLORIDE(80734-02-7)Related Product Information
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- LENAMPICILLIN HYDROCHLORIDE