5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Basic information
- Product Name:
- 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
- Synonyms:
-
- 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
- AN-2718
- 5-Chloro-1,3-dihydro-2,1-benzoxaborol-1-ol, 95%
- 5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol
- 5-Chloro-2,1-benzoxaborol-1(3H)-ol
- 2,1-Benzoxaborole, 5-chloro-1,3-dihydro-1-hydroxy-
- Inhibitor,AN2718,AN 2718,Fungal,AN-2718,inhibit
- AN2718, 10 mM in DMSO
- CAS:
- 174672-06-1
- MF:
- C7H6BClO2
- MW:
- 168.39
- Product Categories:
-
- API
- Mol File:
- 174672-06-1.mol
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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Chemical Properties
- Melting point:
- 150-154 °C
- Boiling point:
- 273.2±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL
- form
- A crystalline solid
- pka
- 6.60±0.20(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C7H6BClO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
- InChIKey
- HMAFTPZYFJFEHK-UHFFFAOYSA-N
- SMILES
- B1(O)C2=CC=C(Cl)C=C2CO1
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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Usage And Synthesis
Uses
AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
Biological Activity
AN-2718 inhibits the growth of fungi by inhibiting protein synthesis through the OBORT mechanism.
in vitro
AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus , and from yeasts, C. albicans , with an IC 50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T. mentagrophytes .
target
Fungal.
References
[1] Seiradake, et al. Antifungal activity and mechanism of action of a benzoxaborole, AN2718, which is in development for the treatment of tinea pedis. 48th Annual ICAAC/46th Annual IDSA (2008).
5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaboroleSupplier
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5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole(174672-06-1)Related Product Information
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