ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > TP-3654
TP-3654
TP-3654 Basic information
- Product Name:
- TP-3654
- Synonyms:
-
- TP3654
- TP-3654
- CS-2702
- TP3654 ;TP 3654
- Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-
- TP3654,inhibit,Pim,TP 3654,Pim kinases,Inhibitor,TP-3654
- 2-(trans-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
- TP-3654, 10 mM in DMSO
- CAS:
- 1361951-15-6
- MF:
- C22H25F3N4O
- MW:
- 418.46
- Product Categories:
-
- API
- Mol File:
- 1361951-15-6.mol
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TP-3654 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:86.0(Max Conc. mg/mL);200.74(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);14.34(Max Conc. mM) - form
- A crystalline solid
- color
- White to light yellow
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TP-3654 Usage And Synthesis
Uses
TP-3654 is a second-generation PIM inhibitor, displaying submicromolar activity in pharmacodynamic biomarker modulation, cell proliferation studies, and colony formation assays.
in vivo
Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity[1].
TP-3654Supplier
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com