CALPAIN INHIBITOR II Chemical Properties

Boiling point:

676.5±55.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

ethanol: 20 mg/mL

form 

powder

pka

13.32±0.46(Predicted)

color 

white

CAS DataBase Reference

110115-07-6(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

CALPAIN INHIBITOR II Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Definition

ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.

General Description

A cell-permeable inhibitor of calpain I (K_i = 120 nM), calpain II (K_i = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

CALPAIN INHIBITOR II(110115-07-6)Related Product Information

• Bismuth hydroxide nitrate oxide, BiO5.1
• CALPAIN INHIBITOR I
• Calpain Inhibitor I
• CALPAIN INHIBITOR II
• H-TRP-TRP-GLY-TRP-GLY-THR-MET-LEU-LEU-GLY-LEU-LEU-MET-ILE-CYS-OH
• GTMLLGLLMICSATE
• H-LEU-GLY-LEU-LEU-MET-ILE-CYS-SER-ALA-THR-GLU-LYS-LEU-TRP-VAL-OH
• FUSION GLYCOPROTEIN (92-106) [HUMAN RESPIRATORY SYNCYTIAL VIRUS]
• BIOTINYL-NEUROPEPTIDE W-23 (HUMAN)
• CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL)
• H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-OH
• EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 3 GAMMA (242-250) [HOMO SAPIENS]/[RATTUS NORVEGICUS]
• H2N-SLLMWITQV-OH
• ALPHA-1 ANTITRYPSIN FRAGMENT [HOMO SAPIENS]/[PAPIO HAMADRYAS]/[CERCOPITHECUS AETHIOPS]
• BIOT-PKPPKPVSKMRMATPLLMQA-OH
• AC-CCLLMPPPPPLFPPPFF-AMIDE
• CD74 ANTIGEN (INVARIANT POLYPEPTIDE OF MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II ANTIGEN-ASSOCIATED) (98-117) [HOMO SAPIENS]
• N-ACETYL-LEU-LEU-MET-H