1-DEOXY-1-(OCTYLAMINO)-D-GLUCITOL Chemical Properties

Melting point:

121-124 °C(lit.)

Boiling point:

524.7±50.0 °C(Predicted)

alpha 

-15 º (c=1, MeOH)

Density 

1.139±0.06 g/cm3(Predicted)

refractive index 

-19 ° (C=0.5, MeOH)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)

form 

Solid

pka

13.47±0.20(Predicted)

color 

White to Off-White

optical activity

[α]20/D 15°, c = 1 in methanol

InChI

InChI=1S/C14H31NO5/c1-2-3-4-5-6-7-8-15-9-11(17)13(19)14(20)12(18)10-16/h11-20H,2-10H2,1H3/t11-,12+,13+,14+/m0/s1

InChIKey

ZRRNJJURLBXWLL-REWJHTLYSA-N

SMILES

C(NCCCCCCCC)[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

CAS DataBase Reference

23323-37-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

HS Code 

29221990

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

1-DEOXY-1-(OCTYLAMINO)-D-GLUCITOL Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

1-Deoxy-1-(octylamino)-D-glucitol is used in the preparation of Dexketoprofen Trometamol.

Synthesis

(1) Preparation of catalyst: 30g NaOH dissolved in 120ml of water, ice water bath cold to zero degree, electric stirring slowly add 30g aluminum - nickel alloy, reaction below 25 degrees Celsius for 2-3 hours, continue stirring for 0.5 hours, placed at room temperature for 2-3 hours, warmed to 95-100 degrees Celsius to continue the reaction for 2-3 hours, washed with water to neutral, and then washed with ethanol 3 times. The prepared RaneyNi was kept under ethanol level for storage. 2) Preparation of co-catalyst ZCMT 3??Preparation of Glucosamine: put n-octylamine, glucose, solvent and catalyst into a high-pressure reactor according to a certain proportionate amount, seal it, pass hydrogen to 1.2~1.4Mpa, raise the temperature to 55~65 degrees Celsius, after 2 hours of reaction, cool and precipitate the white crystals, filter it, and dry it for 2 hours at 70 degrees Celsius, and then get the product. After the reaction was completed, the reaction solution was allowed to cool naturally, the product crystallized, separated by centrifugation, and the product was washed twice with mixed solvents and dried to obtain the product.

1-DEOXY-1-(OCTYLAMINO)-D-GLUCITOL(23323-37-7)Related Product Information

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