Uridine, 2',5'-dideoxy-5'-iodo- Chemical Properties

Melting point:

163-164 °C(Solv: ethanol (64-17-5))

Density 

1.987±0.06 g/cm3(Predicted)

pka

9.39±0.10(Predicted)

Uridine, 2',5'-dideoxy-5'-iodo- Usage And Synthesis

Uses

2′,5′-Dideoxy-5′-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

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