3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Chemical Properties

Melting point:

>165°C (dec.)

Boiling point:

575.7±50.0 °C(Predicted)

Density 

1.173±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at -20°C

solubility 

DMSO (Slightly), Water (Slightly)

pka

10.15±0.40(Predicted)

form 

Solid

color 

Pale Beige to Light Beige

Stability:

Hygroscopic

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Usage And Synthesis

Uses

Roxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist.

Definition

ChEBI: Roxindole is a member of indoles. It has a role as an alpha-adrenergic antagonist and a serotonergic drug.

Biological Activity

Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .

in vivo

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE(112192-04-8)Related Product Information

• ROXINDOLE MESYLATE
• 3-(4-(4-PHENYL-1,2,3,6-TETRAHYDRO-1-PYRIDYL)BUTYL)INDOLE, HCL
• 1,2,3,6-Tetrahydro-4-phenyl-pyridine
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
• 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
• 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE